Showing posts with label Health. Show all posts
Showing posts with label Health. Show all posts

Biogen says Lou Gehrig’s disease drug fails in trial






(Reuters) – An experimental drug to combat amyotrophic lateral sclerosis, commonly called Lou Gehrig‘s disease in the United States, failed to work in an important trial and Biogen Idec said it would stop development of the treatment.


The drug, dexpramipexole, had shown promise and seemed to work against ALS in a mid-stage clinical trial in 2011.






Biogen shares fell 6 percent in premarket trading on Thursday.


ALS is a disease of nerve cells in the brain and spinal cord that affects about 30,000 Americans, according to the ALS Association. About 5,600 Americans are diagnosed with the disease each year. American baseball player Henry Louis “Lou” Gehrig died of the disease in 1941.


There is currently only one drug that is used to help people with ALS – Rilutek, or riluzole, made by Sanofi. It has been shown to prolong the life of people with ALS, who have a life expectancy of two to five years after diagnosis.


The news was an uncommon blow for a company that has excelled in recent years and could push shares down about 10 percent, Mark Schoenebaum, a biotech analyst at ISI Group, said in an early research note.


He said analysts had estimated sales for the drug in 2016 of about $ 350 million – or about 4 percent of Biogen revenue.


The late-stage dexpramipexole trial, which was called Empower and enrolled 943 people with ALS at 81 sites in 11 countries, did not show that the drug increased the ability of people with the disease to function or improved their survival rates.


“We share the disappointment of members of the ALS community, who had hoped that dexpramipexole would offer a meaningful new treatment option,” Biogen Executive Vice President of Research and Development Douglas Williams said in a statement.


The company said it would continue to work on potential treatments for the disease.


(Reporting by Caroline Humer in New York and Esha Dey in Bangalore; Editing by Roshni Menon, Nick Zieminski and John Wallace)


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Women Lose Half Their Weight: How They Did It






At 25 years old and 288 pounds, Ashley Donahoo was depressed.


“I was unhappy with my job, I was unhappy with the direction my life was going, and I had a hard time enjoying the little things that my kids wanted to do,” the 27-year-old mother of two from Pace, Fla., said. “My health was failing. My doctor told me that he didn’t think I was going to make it to 30 if I kept on [this way]. … It kept getting worse and worse.”






Donahoo was concerned, but it was her faithful husband, David, who pushed her on a path to health, starting with a walk around the block.


“His heart was breaking for me,” she said. “And he saw how unhappy I was, and he came to me and said, ‘We’re going to go for a walk.’  And I was, like, ‘No, we’re not.’”


Her husband won that battle, and on the walk, she started thinking about her own choices and future.


“The realization hit me that I made this choice.  I made this choice to get where I am right now.  So I’m going to start making a different choice,” she said.   ”I put my health and myself on back burner, and I think … it had all caught up to me.”


Jumpstart Your Weight Loss: CLICK HERE to Ask a Celebrity Trainer a Question!


Like Donahoo, Caroline Jhingory reached a similar eye-opening realization about her weight.


“I looked in the mirror one day and just realized I didn’t recognize the person that was staring back at me,” said Jhingory, 32, of Washington, D.C.


Jhingory’s struggles with her weight began early. At age 8, she weighed 120 pounds. Taunted by her peers, Jhingory was enrolled in a medical weight loss program, but it didn’t work because she would sneak junk food like candy bars.


“I found a way to be a food hustler and get whatever food I wanted,” she said. “Not only did I spend two decades of my life morbidly obese. I spent two decades of my life being taunted and teased in every environment. I never went to prom. I never had dates. I couldn’t ride a roller coaster because the safety bar wouldn’t go over my stomach.”


Jhingory remained heavy until college, when she tipped the scales at 303 pounds and started feeling self-conscious in her new environment.


“I felt like I had a moment when all these difficult experiences were a huge pause button on my life. I finally said to myself, ‘I’m tired of this. I want to have a normal life.’”


Jhingory started walking everywhere. Then, she took up a daily cardio regimen to shed the weight, and she rid her pantry of tempting snack foods she once binged on. Now 149 pounds, she has reclaimed her shape and kept off the weight.


Jhingory’s amazing transformation, along with Donahoo’s and other weight-loss success stories, were spotlighted in the “Half Their Size” feature in the latest issue of People magazine.


RELATED: Is Being Overweight Really Bad For You?


Donahoo cut out the late-night binges that brought her down and, thanks to her strong support system, lost 137 pounds. She credited her weight loss success to tracking her food and exercise on livestrong.com and running. She has run two 5Ks.


Leah Fernandez of Atlanta found herself at 251 pounds after two pregnancies. The baby weight stuck and she tended to eat emotionally.


“I wanted the food,” she said. “It made me feel good, and so I ate it.”


But it was the motivation to be there for her children that helped her turn it all around.


“Thinking about going out to the park with my kids felt like work to me, you know?  And at some point I realized that’s ridiculous. Not only am I cheating myself but I’m cheating my kids of me,” she said.


Fernandez turned to Jenny Craig in March 2011 and hasn’t looked back. Since then, she has lost half her weight by staying active with her kids and incorporating walking into her lifestyle.


“I’m getting my groove back.  Leah’s getting her groove back,” she said.


RELATED: Apps to Help With Weight-Loss Resolutions


RELATED: 329 Pound-Weight-Loss Trio Share Their Secrets


READ MORE: 138 Pound Weight Loss Changes Woman’s Life


Health News Headlines – Yahoo! News





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Clinton receiving blood thinners to dissolve clot






WASHINGTON (AP) — Doctors treating Secretary of State Hillary Rodham Clinton for a blood clot in her head said blood thinners are being used to dissolve the clot and they are confident she will make a full recovery.


Clinton didn’t suffer a stroke or neurological damage from the clot that formed after she suffered a concussion during a fainting spell at her home in early December, doctors said in a statement Monday.






Clinton, 65, was admitted to New York-Presbyterian Hospital on Sunday when the clot turned up on a follow-up exam on the concussion, Clinton spokesman Phillipe Reines said.


The clot is located in the vein in the space between the brain and the skull behind the right ear. She will be released once the medication dose for the blood thinners has been established, the doctors said.


In their statement, Dr. Lisa Bardack of the Mount Kisco Medical Group and Dr. Gigi El-Bayoumi of George Washington University said Clinton was making excellent progress and was in good spirits.


Clinton’s complication “certainly isn’t the most common thing to happen after a concussion” and is one of the few types of blood clots in the skull or head that are treated with blood thinners, said Dr. Larry Goldstein, a neurologist who is director of Duke University’s stroke center. He is not involved in Clinton’s care.


The area where Clinton’s clot developed is “a drainage channel, the equivalent of a big vein inside the skull. It’s how the blood gets back to the heart,” Goldstein said.


Blood thinners usually are enough to treat the clot and it should have no long-term consequences if her doctors are saying she has suffered no neurological damage from it, Goldstein said.


Clinton returned to the U.S. from a trip to Europe, then fell ill with a stomach virus in early December that left her severely dehydrated and forced her to cancel a trip to North Africa and the Middle East. Until then, she had canceled only two scheduled overseas trips, one to Europe after breaking her elbow in June 2009 and one to Asia after the February 2010 earthquake in Haiti.


Her condition worsened when she fainted, fell and suffered a concussion while at home alone in mid-December as she recovered from the virus. It was announced Dec. 13.


This isn’t the first time Clinton has suffered a blood clot. In 1998, midway through her husband’s second term as president, Clinton was in New York fundraising for the midterm elections when a swollen right foot led her doctor to diagnose a clot in her knee requiring immediate treatment.


Clinton had planned to step down as secretary of state at the beginning of President Barack Obama’s second term. Whether she will return to work before she resigns remained a question.


Democrats are privately if not publicly speculating: How might her illness affect a decision about running for president in 2016?


After decades in politics, Clinton says she plans to spend the next year resting. She has long insisted she had no intention of mounting a second campaign for the White House four years from now. But the door is not entirely closed, and she would almost certainly emerge as the Democrat to beat if she decided to give in to calls by Democratic fans and run again.


Her age — and thereby health — would probably be a factor under consideration, given that Clinton would be 69 when sworn in, if she were elected in 2016. That might become even more of an issue in the early jockeying for 2016 if what started as a bad stomach bug becomes a prolonged, public bout with more serious infirmity.


Not that Democrats are willing to talk openly about the political implications of a long illness, choosing to keep any discussions about her condition behind closed doors. Publicly, Democrats reject the notion that a blood clot could hinder her political prospects.


“Some of those concerns could be borderline sexist,” said Basil Smikle, a Democratic strategist who worked for Clinton when she was a senator. “Dick Cheney had significant heart problems when he was vice president, and people joked about it. He took the time he needed to get better, and it wasn’t a problem.”


It isn’t uncommon for presidential candidates’ health — and age — to be an issue. Both in 2000 and 2008, Sen. John McCain, R-Ariz., had to rebut concerns he was too old to be commander in chief or that his skin cancer could resurface.


Two decades after Clinton became the first lady, signs of her popularity — and her political strength — are ubiquitous.


Obama had barely declared victory in November when Democrats started zealously plugging Clinton as their strongest White House contender four years from now, should she choose to take that leap.


“Wouldn’t that be exciting?” House Democratic leader Nancy Pelosi declared in December. “I hope she goes. Why wouldn’t she?”


Even Republicans concede that were she to run, Clinton would be a force to be reckoned with.


“Trying to win that will be truly the Super Bowl,” Newt Gingrich, the former House Speaker and 2012 GOP presidential candidate, said in December. “The Republican Party today is incapable of competing at that level.”


Americans admire Clinton more than any other woman in the world, according to a Gallup poll released Monday — the 17th time in 20 years that Clinton has claimed that title. And a recent ABC News/Washington Post poll found that 57 percent of Americans would support Clinton as a candidate for president in 2016, with just 37 percent opposed. Websites have already cropped up hawking “Clinton 2016″ mugs and tote bags.


Beyond talk of future politics, Clinton’s three-week absence from the State Department has raised eyebrows among some conservative commentators who questioned the seriousness of her ailment after she canceled planned Dec. 20 testimony before Congress on the deadly attack on the U.S. diplomatic mission in Benghazi, Libya.


Clinton had been due to discuss with lawmakers a scathing report she had commissioned on the attack. It found serious failures of leadership and management in two State Department bureaus were to blame for insufficient security at the facility. Clinton took responsibility for the incident before the report was released, but she was not blamed. Four officials cited in the report have either resigned or been reassigned.


___


Associated Press writer Ken Thomas in Washington and AP Chief Medical Writer Marilynn Marchione in Milwaukee contributed to this report.


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Vomiting Larry battles “Ferrari of the virus world”






LONDON (Reuters) – Poor Larry isn’t looking too good. He’s pale and clammy and he’s been projectile vomiting over and over again while his carers just stand by and watch.


Yet their lack of concern for Larry is made up for by their intense interest in how far splashes of his vomit can fly, and how effectively they evade attempts to clean them up.






Larry is a “humanoid simulated vomiting system” designed to help scientists analyze contagion. And like millions around the world right now, he’s struggling with norovirus – a disease one British expert describes as “the Ferrari of the virus world”.


“Norovirus is one of the most infectious viruses of man,” said Ian Goodfellow, a professor of virology at the department of pathology at Britain‘s University of Cambridge, who has been studying noroviruses for 10 years.


“It takes fewer than 20 virus particles to infect someone. So each droplet of vomit or gram of feces from an infected person can contain enough virus to infect more than 100,000 people.”


Norovirus is hitting hard this year – and earlier too.


In Britain so far this season, more than a million people are thought to have suffered the violent vomiting and diarrhea it can bring. The Health Protection Agency (HPA) said this high rate of infection relatively early in the winter mirrors trends seen in Japan and Europe.


“In Australia the norovirus season also peaks during the winter, but this season it has gone on longer than usual and they are seeing cases into their summer,” it said in a statement.


In the United States, the Centers for Disease Control and Prevention (CDC) say norovirus causes 21 million illnesses annually. Of those who get the virus, some 70,000 require hospitalization and around 800 die each year.


PROFUSE AND PROJECTILE


Norovirus dates back more than 40 years and takes its name from the U.S. city of Norwalk, Ohio, where there was an outbreak of acute gastroenteritis in school children in November 1968.


Symptoms include a sudden onset of vomiting, which can be projectile, and diarrhea, which may be profuse and watery. Some victims also suffer fevers, headaches and stomach cramps.


John Harris, an expert on the virus at Britain’s HPA, puts it simply: “Norovirus is very contagious and very unpleasant.”


What makes this such a formidable enemy is its ability to evade death from cleaning and to survive long periods outside a human host. Scientists have found norovirus can remain alive and well for 12 hours on hard surfaces and up to 12 days on contaminated fabrics such as carpets and upholstery. In still water, it can survive for months, maybe even years.


At the Health and Safety Laboratory in Derbyshire, northern England, where researcher Catherine Makison developed the humanoid simulated vomiting system and nicknamed him “Vomiting Larry”, scientists analyzing his reach found that small droplets of sick can spread over three meters.


“The dramatic nature of the vomiting episodes produces a lot of aerosolized vomit, much of which is invisible to the naked eye,” Goodfellow told Reuters.


Larry’s projections were easy to spot because he had been primed with a “vomitus substitute”, scientists explain, which included a fluorescent marker to help distinguish even small splashes – but they would not be at all easily visible under standard white hospital lighting.


Add the fact that norovirus is particularly resistant to normal household disinfectants and even alcohol hand gels, and it’s little wonder the sickness wreaks such havoc in hospitals, schools, nursing homes, cruise ships and hotels.


During the two weeks up to December 23, there were 70 hospital outbreaks of norovirus reported in Britain, and last week a cruise ship that sails between New York and Britain’s Southampton docked in the Caribbean with about 200 people on board suffering suspected norovirus.


MOVING TARGET


The good news, for some, is that not everyone appears to be equally susceptible to norovirus infection. According to Goodfellow, around 20 percent of Europeans have a mutation in a gene called FUT2 that makes them resistant.


For the rest the only likely good news will have to wait for the results of trials of a potential norovirus vaccine developed by U.S. drugmaker LigoCyte Pharmaceuticals Inc, or from one of several research teams around the world working on possible new antiviral drugs to treat the infection.


Early tests in 2011 indicated that around half of people vaccinated with the experimental shot, now owned by Japan’s Takeda Pharmaceutical Co, were protected from symptomatic norovirus infection.


The bad news, virologists say, is that the virus changes constantly, making it a moving target for drug developers. There is also evidence that humans’ immune response to infection is short-lived, so people can become re-infected by the same virus within just a year or two.


“There are many strains, and the virus changes very rapidly – it undergoes something virologists call genetic drift,” Harris said in a telephone interview. “When it makes copies of itself, it makes mistakes in those copies – so each time you encounter the virus you may be encountering a slightly different one.”


This means that even if a vaccine were to be fully developed – still a big ‘if’ – it would probably need to be tweaked and repeated in a slightly different formula each year to prevent people getting sick.


Until any effective drugs or vaccines are developed, experts reckon that like the common cold, norovirus will be an unwelcome guest for many winters to come. Their advice is to stay away from anyone with the virus, and use soap and water liberally.


“One of the reasons norovirus spreads so fast is that the majority of people don’t wash their hands for long enough,” said Goodfellow. “We’d suggest people count to 15 while washing their hands and ensure their hands are dried completely.”


(Reporting by Kate Kelland; Editing by Will Waterman)


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Obama says failure to reach fiscal deal would hurt markets






WASHINGTON (Reuters) – Financial markets would be affected adversely if U.S. lawmakers fail to agree on a “fiscal cliff” deal before Tuesday, President Barack Obama said in an interview broadcast on Sunday, while urging Congress to act quickly to extend tax cuts for middle-class Americans.


Lawmakers are seeking a last-minute deal that would set aside $ 600 billion in tax increases and across-the-board government spending cuts that are set to start within days. If Congress does not make that happen, the first bill brought up in the new year would be to reduce taxes for middle-income families, Obama told NBC’s “Meet the Press.”






“Now I think that over the next 48 hours, my hope is that people recognize that, regardless of partisan differences, our top priority has to be to make sure that taxes on middle-class families do not go up. That would hurt our economy badly,” Obama said in the interview taped on Saturday.


“We can get that done. Democrats and Republicans both say they don’t want taxes to go up on middle-class families. That’s something we all agree on. If we can get that done, that takes a big bite out of the ‘fiscal cliff.’ It avoids the worst outcomes,” Obama added.


Low income tax rates first put in place under Republican former President George W. Bush are due to expire at the end of the day on Monday – the last day of 2012.


Obama said that failing to reach a deal would have a negative impact on financial markets.


“If people start seeing that on January 1st this problem still hasn’t been solved, that we haven’t seen the kind of deficit reduction that we could have had had the Republicans been willing to take the deal that I gave them … then obviously that’s going to have an adverse reaction in the markets,” he said.


RARE SENATE SESSION ON SUNDAY


Obama met with congressional leaders at the White House on Friday and declared himself cautiously optimistic about the chances of an agreement, but he noted in the interview that nothing had materialized since then.


“I was modestly optimistic yesterday, but we don’t yet see an agreement. And now the pressure’s on Congress to produce,” he said.


The Senate is scheduled to hold a rare Sunday session beginning at 1 p.m. EST (1800 GMT), but it was not clear whether the chamber would have fiscal-cliff legislation to act upon.


Obama sketched out what he believed to be the most likely scenarios the end the back-and-forth between both sides. Either the congressional leaders would come up with a deal, or Democrats in the Senate would bring a bill to the floor seeking an up-or-down vote to extend tax cuts for middle income earners.


“And if all else fails, if Republicans do in fact decide to block it, so that taxes on middle class families do in fact go up on January 1st, then we’ll come back with a new Congress on January 4th and the first bill that will be introduced on the floor will be to cut taxes on middle class families,” he said.


Obama chided Republicans for resisting his call for tax rates to go up for the top two percent of U.S. earners despite what he viewed as significant compromises on his part to cut spending and reform expensive social programs for the poor and elderly.


“They say that their biggest priority is making sure that we deal with the deficit in a serious way, but the way they’re behaving is that their only priority is making sure that tax breaks for the wealthiest Americans are protected. That seems to be their only overriding, unifying theme,” Obama said.


“The offers that I’ve made to them have been so fair that a lot of Democrats get mad at me. I mean I offered to make some significant changes to our entitlement programs in order to reduce the deficit,” he said.


(Reporting by Jeff Mason; Editing by David Brunnstrom)


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‘Frankenfish’ Nears FDA Approval as Debate Heats up






Genetically engineered salmon could make its way onto plates in the new year, but your body won’t notice anything fishy about the filet, experts say.


The Food and Drug Administration has determined genetically engineered salmon won’t threaten the environment, clearing it of all but one final hurdle before it shows up on shelves throughout the nation — and igniting a final 60-day debate on whether it poses health risks before it’s officially approved.






Although it’s been nicknamed “Frankenfish” by critics, health professionals say they aren’t worried the lab-engineered salmon will cause more allergies or other harmful effects than any other breed of fish.


“The hard science part is that we have been creating [animals] using genes and natural selection for years to genetically predict what kinds of food animals, and recreational animals and such we have on our planet,” said Dr. William Schaffner, chairman of preventive medicine at Vanderbilt University Medical Center in Nashville, Tenn.


He cited thoroughbred horses, show dogs and crops as examples of genetically engineered plants and animals dating back centuries.


“When Farmer Jones did it in his cornfield to try to get a better crop, it didn’t bother people,” Schaffner said. “When scientist Jones did the same thing in a much more sophisticated fashion in a lab, that does bother people.”




Superfish: DNA-Altered Salmon Coming to Your Dinner Plate? Watch Video





California’s ‘Frakenfood’ Vote, Legalization of Gay Marriage, Pot Watch Video



A biotech company in Massachusetts called AquaBounty created the AquaAdvantage salmon, which is really an Atlantic salmon with an added Pacific salmon gene to make it grow faster and an added eel gene to make it grow year-round.


The end result is a fish that tastes like an Atlantic salmon but grows twice as fast, making it cheaper to produce and sell. Because the FDA likely won’t require a label that says the salmon was genetically modified, consumers won’t know the difference.


Click here to read about ABC News’ exclusive look at the AquaBounty facility.


Schaffner thinks genetically engineered food is one way to help solve world hunger and, as long as the FDA thoroughly reviews it, there shouldn’t be a problem.


But Rep. Dennis Kucinich, D-Ohio, said he’s been disappointed with FDA decisions on genetically modified food since 1992, when the FDA determined it is equivalent to any other food. He said there’s not enough science to allow AquaAdvantage onto our dinner plates, but the biotech industry has had so much influence in Congress that it’s been impossible to stop.


“Now this latest action by the FDA somehow determined that the salmon is safe — safe for who?” he asked. “Safe for the investors?”


Kucinich has introduced legislation related to genetically modified food and labeling in every Congress since 1997, but it has never passed. He said Monsanto, the $ 2 billion company that produces genetically modified seed and pesticides, is partially to blame because it has so much money and influence.


AquaBounty, the biotech firm that makes AquaAdvantage, contributed less than $ 150,000 toward lobbying Congress over the last three years, according to campaign finance records available on OpenSecrets.org. In contrast, Monsanto spent more than $ 19 million lobbying over the same time frame.


Kucinich said the AquaAdvantage issue is a complex one, and worries about whether the genetically altered fish will hurt naturally occurring wild fish populations by overfeeding because they grow twice as fast as their naturally occurring relatives. However, the most recent FDA finding showed that this is not a concern because the fish are mostly sterile and not expected to escape their man-made farms.


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Kenya hospital imprisons new mothers with no money






NAIROBI, Kenya (AP) — The director of the Pumwani Maternity Hospital, located in a hardscrabble neighborhood of downtown Nairobi, freely acknowledges that he detains mothers who can’t pay their bills.


Lazarus Omondi says it’s the only way he can keep his medical center running. Now, a New York-based group filed a lawsuit this month in hopes of forcing Pumwani to stop the practice.






Two mothers who live in a mud-wall and tin-roof slum near the maternity hospital said Pumwani wouldn’t let them leave after delivering their babies. The bills the mothers couldn’t afford were $ 60 and $ 160. Guards with sticks would beat mothers who tried to leave without paying, one of the women said.


Omondi says one solution to the problem would be a national health insurance program.


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Light Therapy Helps Ease Winter Blues






Every October as the clocks are turned back, Jose Balido notices that his mood changes, almost as if his body were going into hibernation.


His limbs are heavy and he has trouble moving around. Simple household chores like loading the dishwasher seem “insurmountable,” he said. But when spring arrives, the lethargy lifts.






“It took me a while to realize what it was,” said Balido, owner of a travel social network site, Tripatini. “I was cranky, short-tempered, depressed, feeling hopeless and having difficulty concentrating.”


Balido, 51, was diagnosed a decade ago with seasonal affective disorder or SAD. The condition affects 62 million Americans, according to Michael Terman, director of the Center for Light Treatment and Biological Rhythms at Columbia University and a leader in the field.


About 5 percent of the population experiences the most severe symptoms of SAD — depression and hopelessness — while another 15 percent have the so-called “winter blues” or “winter doldrums.”


The vast majority never fall into full depression, according to Terman, but “plod through winters with slowness and gloominess that takes effort to hide from others.”


Two decades ago, SAD was identified as a legitimate disorder by the National Institute of Mental Health. Since then, the treatment of choice has been light therapy.


Balido, who lives in Miami, sought help from Terman and now undergoes light therapy. He sits in front of a daylight simulator for a half an hour each morning before 10 a.m.


“Within two or three days, the difference was mind-blowing,” he said.


The standard treatment for SAD is 30 minutes of 10,000-lux, diffused, white fluorescent light, used early in the morning. About half the patients are helped quickly — and when treatment is tailored to a person’s individual wake-sleep cycle, remission can climb to 80 percent, according to Terman.


This year, a utility company in the northern Swedish town of Umea installed ultraviolet lights at 30 bus stops to combat the effects of SAD.


“We wanted to celebrate the fact that all our electricity comes from green sources and we wanted to do this in a way that contributed to the citizens in one way or another,” said Umea Energi marketing chief Anna Norrgard in an email to ABCNews.com.


“As it is very dark where we live this time of year, a lot of us are longing for the daylight,” she said. “A lot of us are also a bit more tired this time of year and I would also say we sleep a little bit more. …We wanted to give the citizens of Umea a little energy boost, to be more alert.”


The town is located about 400 miles north of Stockholm. In December, the sun rises at about 10 a.m. and sets around 2:30 p.m. Some towns north of the Arctic Circle have no daylight for several weeks in the winter.


Geography has a strong influence on the prevalence of SAD symptoms, according to Terman.


“The common wisdom is that it’s worse the farther north you live, because winter days are so much shorter,” he said. “Not so simple.”


Columbia research shows that in North America, the incidence of SAD rises from the southern to the middle states, but levels off and stays bad from about 38 degrees North latitude (near such cities as San Francisco, St. Louis and Washington, D.C.) up through the northernmost states and Canada, according to Terman.


But the problem becomes “more severe” at the western edges of the northern states and provinces.


“This important finding reveals the underlying trigger for relapses into winter depression, since the sun rises an hour more later at the western edge of a zone,” said Terman, whose book, “Chronotherapy,” looks at the phenomenon.


Esther Kane, a clinical counselor from Vancouver, Canada, said her practice is filled with patients as the long days descend on British Columbia.


Seasonal Affective Disorder Hits Hard in Canada


“On the West Coast where we live it’s so rampant, I can’t even tell you how many people have it,” said Kane. “Everyone is feeling it with the gray skies and rain. It’s like nighttime all the time here.”


Doctors there routinely prescribe fish oil and vitamin D, as well as light therapy to balance out the sleep hormone melatonin and “boost” the feel-good hormone serotonin, according to Kane. Many are also on antidepressants.


“A lot of people depend on alcohol and drugs all of a sudden,” she said. “They are stuffing themselves with carbs and their food intake is up. They have depression symptoms — what’s the point of getting out of bed in the morning when they feel no energy and there is dark all over them?”


“Some suffer so bad, they can’t function,” said Kane. “Everyone here who can afford to get away for two weeks in the winter, go to Hawaii.”


Even those who live south of the Mason-Dixon Line in the United States can be affected.


Tina Saratsiotis, who works for a faith-based nonprofit group in Towson, Md., was surprised to develop SAD several years ago.


“I used to be a night person and like the dark. Then something changed,” she said. “By fall when it gets darker and the fatigue and sadness comes and by Christmas, it’s difficult to function.”


“It creeps in slowly — I eat more and have trouble concentrating,” she said. “I am more irritable and weeping, like a prolonged version of PMS. It makes it hard to get things done and to enjoy things.”


Columbia’s Terman said there may be genetic influences in who gets SAD — a vulnerability to depression and to insufficient light exposure.


SAD sufferers say it’s especially hard on their relationships when their winter moods kick in.


“Now, he’s very understanding,” said Saratsiotis, who uses both light therapy and antidepressants to deal with the condition. “But before, when I didn’t feel up to going out, I couldn’t explain not feeling great. People wonder, ‘Why doesn’t she like me?’ and, ‘She’s no fun.’”


But when spring rolls around, so does her old self.


“I love the solstice — thank you, Lord, for the solstice,” she said. “I really need [the medication] now, but I may not in the spring and summer.”


But now, in when the days are their shortest, SAD puts a crimp on the holidays.


“It kills Christmas,” said Saratsiotis. “I sit in the middle of the department store with that particular song about the sleigh bells ringing, and I am sobbing. I burst into tears and think, ‘Just kill that song.’”


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Top 7 Holiday Allergy Triggers







When you wheeze through your fa-la-la’s and your nose rivals Rudolph’s, it’s a little tougher to feel jolly. Although allergies peak in the spring and fall, the holidays may surprise sensitive sufferers with a gift of unexpected triggers, from dusty decorations and potent potpourri to even — say it ain’t so — the Christmas tree.


Here are seven yuletide allergens, and expert tips to help you stay focused on shopping and wrapping, not sneezing and scratching.






How To Keep Your Allergies From Ruining Your Day




Holiday Allergy Triggers


That’s right — the one and only, the centerpiece of all things Christmas, that perfect fir you found hiding in the lot of freshly-cut trees that’s now twinkling with the lights you spent hours untangling — may be to blame for your stuffy nose, watery eyes and rash-y skin.


“Mold is the biggest problem with live Christmas trees,” says Dr. Marilyn Li, an asthma and allergy specialist with the Los Angeles County + University of Southern California Medical Center. “Often, they are cut in advance and kept in humid environments, promoting spore growth.”


Within just two weeks of bringing a tree into your home, indoor mold counts can increase significantly, according to one study.


Other tree-related allergens: The sap contains terpene and other substances that can irritate skin and mucous membranes; and pollen stuck to the tree may be released inside and lead to reactions, adds Dr. Nathanael S. Horne, clinical assistant professor of medicine at NYU school of Medicine and fellow of the American Academy of Allergy, Asthma & Immunology. What about the artificial versions? They could harbor dust and mold from their time in storage, also triggering allergies.


Prevent it: Slip on gloves and wear long sleeves when handling your fresh tree to avoid the sap coming into contact with your skin. Before schlepping your tree inside, give it a good shake (or a blast with a leaf blower) and spray it down with a garden hose (especially the trunk) to help remove some of the pollen and mold, suggests Horne. Then sit the stump in a bucket of water and let the tree dry for few days on a covered porch or in a garage. For an allergen-free fake tree, give it a good wipe-down before decorating with lights and ornaments.


4 Holiday Health Busters




Holiday Allergy Triggers


For eleven months out of the year, all your ornaments, lights, and holiday chotchkes sit stored out of sight, collecting dust and maybe developing mold. When the boxes of red, green, and gold goodies come out, the symphony of sneezing, coughing and nose-blowing commences.


Prevent it: Before decking your halls, mantels, windows and trees, wipe down each item thoroughly; when it’s time to repack, store your holiday trimming in airtight containers, and in a dry spot if possible. Also, go easy on the spray snow — you may love the look of frosted windows, but any aerosolized chemical can cause irritant reactions in the eyes, nose or lungs of a sensitive person, says Horne.




Holiday Allergy Triggers


The fact that she makes “Why aren’t you pregnant yet?” the topic of Christmas dinner is enough to make you break out in hives, but the nuts that she baked into her dessert crust could be to blame, too.


If you have food allergies, the holidays in particular are a ripe time for reactions, simply because you’re around so. much. food. The most common food allergens are milk, eggs, soy, fish, shellfish, peanuts, tree nuts, and wheat.


“Of those, peanuts and tree nuts will most often make it into holiday dishes without people knowing, and have the potential to cause severe reactions,” says Horne.


Prevent it: It’s a good idea to let your holiday host know about your food allergies; it’s important to ask about the ingredients in each dish; and it’s very nice to volunteer to bring something that’s safe for you, and shareable with others. But what’s crucial is to be prepared with an epinephrine auto-injector (Epi Pen), an emergency dose of antihistamine, and an inhaler if you have asthma—just in case, adds Li, director of the USC Breathmobile, a pediatric clinic that travels to schools and provides ongoing asthma and allergy care to children. Learn which foods and recipes are unexpected sources of allergens at FoodAllergy.org and AAAAI.org.


How To Prevent Holiday Weight Gain




Holiday Allergy Triggers


You raise a glass to your loved ones, your boss and colleagues, friends and neighbors, and even the strangers sitting next to you at a bar. There’s lots of cheers-ing this time of year, but be mindful of what you’re using to toast. Some people may experience mild wheezing or other symptoms from the sulfites in wine, for example, and certain alcoholic concoctions contain major food allergens.


Prevent it: There aren’t good tests for sulfite sensitivity, but your reaction to dried fruit — high in this sulfur-based preservative — could be an indicator, says Horne. Pay attention if you have asthma, as sulfites can trigger symptoms. Maraschino cherries contain small amounts of sulfites, as well. Stick with organic wine for a sulfite-free sip. Other triggers to be aware of: Tree nuts may be found specialty beers, particularly seasonal ales; milk is in Irish crème and white chocolate liqueurs; and egg whites may be used to add froth to specialty drinks.


Low Calorie Holiday Treats




Holiday Allergy Triggers


This festive plant is a member of the rubber tree family and contains compounds similar to those found in latex, so stay away if you have a latex allergy. Certain groups of people — such as healthcare workers and people with spina bifida who have had numerous surgeries — are more likely to be allergic to latex, says Li, and one study showed that 40 percent of latex-allergic individuals were also allergic to poinsettias.


Prevent it: If you have a latex allergy, keep the iconic plant out of your house—not only can it give you a rash if you touch it, but inhaling the allergen can lead to serious respiratory problems, like shortness of breath and wheezing.


5 Holiday Pet Dangers




Holiday Allergy Triggers


Pine-infused potpourri, dessert-scented candles, cinnamon air sprays — while they will make your house smell like Christmas, they can irritate the nose and throats of allergy-sensitive people.


“Candles in particular are an increasingly recognized source of indoor air pollution,” says Horne. “The same is true for air sprays and other types of air fresheners—they can release many different types of noxious compounds, which can generate adverse reactions in sensitive patients.”


Prevent it: If skipping the scents feels Grinch-like, try making your own potpourri with cinnamon sticks and cloves so you know what’s in the mixture, says Horne. And choose candles made of soy or beeswax, suggests Li. There’s not much smell, but you can still enjoy the warm glow. By the way, fireplaces are an absolute no-no for asthmatic patients — the ash and smoke can trigger an attack, so keep the log unlit.


Attack Allergies With Yoga




Holiday Allergy Triggers


Stress doesn’t cause allergies or asthma by itself, but it can hinder your immune system and be a trigger for asthma attacks, says Horne. Chemicals released by the body during stressful times can cause the muscles around your airways to tighten, making it difficult to breathe.


Prevent it: All the deep breathing in the world probably can’t calm the chaos that comes with the season, but what you can do is make sure you take the steps to stay healthy: Stick to your controller medication regimen and get a flu shot, advises Li.


***


More from Prevention:


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eac2a  img bullet bluedot Top 7 Holiday Allergy TriggersYour Stay-Slim Holiday Survival Plan


eac2a  img bullet bluedot Top 7 Holiday Allergy TriggersAre You Allergic To Wine?


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FDA warns doctors of counterfeit Botox






WASHINGTON (AP) — Federal regulators have warned more than 350 medical practices that Botox they may have received from a Canadian supplier is unapproved and could be counterfeit or unsafe.


The Food and Drug Administration said in a letter sent last month, a letter released publicly last week, that batches of the wrinkle treatment shipped by suppliers owned by pharmacy Canada Drugs have not been approved by the FDA and that the agency cannot assure their effectiveness or their safety.






The FDA said Canada Drugs was previously tied to shipping unapproved and counterfeit cancer drugs.


The agency warned doctors about buying drugs from sources other than licensed U.S. pharmacies. It is the fifth warning the agency has made this year about foreign suppliers providing unapproved drugs.


In February, the agency warned 19 medical practices that they had received a counterfeit version of the cancer drug Avastin. On three more occasions the FDA issued similar warnings about counterfeit Avastin and Altuzan, another brand name for the same drug. The alerts were also primarily targeted at drugs distributed by Canada Drugs.


A request for comment from the drug distributor was not immediately returned.


Drug shortages increased the financial incentives for some pharmacies to provide counterfeit or illegally imported drugs. The drugs subject to warnings have all been injectable treatments typically distributed through medical practices and not directly to patients.


In October, the FDA ordered operators of about 4,100 websites to immediately stop selling unapproved medications to U.S. consumers. The vast majority of those sites were operated by Canada Drugs. The site was still operating Friday.


Genuine Botox is made by Allergan Inc., based in Irvine, Calif. Avastin is made by Roche Holding AG’s Genentech unit.


___


Online:


The FDA’s warning letter, plus a list of doctors who received it: http://1.usa.gov/R7jKiR


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Meanwhile, Deep Inside Your Belly Button …






Dec 23, 2012 7:00am



5846e  gty belly button jt 121222 wblog Meanwhile, Deep Inside Your Belly Button …

Getty Images







Reported by Dr. Amish Patel:


Researchers have found that more than 2,000 different species of bacteria live in our umbilicus – the medical word for belly button.  That means you have more kinds of bacteria in your belly button than there are different kinds of ants or birds in North America, according to the study.


The majority of these bacteria were rare and occurred in just one individual.  No single type was common to all 60 belly buttons sampled.


“I don’t find it alarming,” said Dr. William Schaffner, an expert in infectious diseases at Vanderbilt University Medical Center in Nashville, Tenn.  “We knew belly buttons weren’t sterile.”


However, Schaffner believes that this does not minimize the study’s findings.


“This is in the context of a much larger study, which is trying to … get greater insight into the source of pathogens and how the [bacteria on our body] changes with antimicrobial therapy and age.”


Perhaps, he said, we can “use this to develop new antimicrobials.”


The benefits may extend beyond antibiotics.


“Understanding the biodiversity of our bodies and how it differs among people may play an important role in understanding why some … people are susceptible to the same pathogen or respond to the same drug or diet,” said Dr. Rob Knight, associate professor of molecular biophysics at the University of Colorado – Boulder.


Although the findings of the study do not have any immediate implications, this is good timing for a public service announcement from Dr. Gregory Poland, infectious disease expert at the Mayo Clinic in Rochester, Minn.


“The current fad of women piercing their umbilicus has led to many case reports of infections,” Poland said. “And with today’s multiple drug-resistant bacteria, it can lead to disasters.”



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How the Holidays Hurt Your Sex Drive






Ladies, does all of the cooking, baking, shopping, entertaining, wrapping, and decorating associated with good holiday cheer leave you too jingle-jangled to be naughty OR nice? If so, here’s some good news: There’s probably nothing seriously wrong with you if you prefer catching some shut-eye to knocking boots this time of year. The main factors contributing to low sex drive in women — including younger woman — seem to intensify during the craziness of the holidays.


7 Ways The Holidays Hurt Your Looks






Sex Drive Killers


“There’s no doubt that some women experience low or no desire, and that this troubles them. That said, we need to be more critical about lumping women into low or no desire groups, particularly as some women are not distressed by their lack of desire,” explains sex expert Debby Herbenick, PhD, research scientist at Indiana University and author of Because It Feels Good (Rodale, 2009). “They may not have a particularly warm or kind partner, or they may be very stressed about work or family, or exhausted as they care for a newborn, and may well realize that there are times in life when sex takes a temporary backseat for a good reason.”


Contrary to what you may see on TV, a lull in sexual desire isn’t always a crisis. “We should challenge ideas that suggest that women or men should always want lots of sex, all the time,” Herbenick says.


In a 2010 study published in the Journal of Sexual Medicine, researchers looked at 400 premenopausal women age 18 or older with low sexual desire disorder. (The researchers estimate that seven to 12 percent of the female population lives with decreased sexual desire and associated distress.) In the study, it turned out that 85 percent of the low-sex-drive women cited multiple factors for their low drive. Here are the main culprits.


1. Stress or fatigue (60 percent of study participants said these factors contribute to low sex drive)


2. Dissatisfaction with personal appearance (41 percent)


3. Sexual difficulties, including problems reaching orgasm (34 percent)


The study authors conclude that boosting self-esteem, along with reducing fatigue and stress, could significantly fire up a woman’s sex life.


Holiday Relationship Rescue


***


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European watchdog starts safety review of Merck cholesterol drug






LONDON (Reuters) – The European Medicines Agency said it has launched a review of Merck & Co Inc‘s cholesterol drug Tredaptive after the medicine failed a U.S. trial assessing its effectiveness and safety.


Although the commercial fallout from any decision to pull the drug from the market in Europe would be limited, it would be a blow to Merck‘s reputation.






Bernstein analyst Tim Anderson estimates that Tredaptive sales in Europe and other non-U.S. markets are running at only around $ 50 million a year, compared to Merck’s overall revenue of $ 47 billion.


The drug is designed to raise “good” HDL cholesterol but the 25,000 patient study found it didn’t do better at preventing heart attacks, deaths or strokes than traditional statin drugs that lower “bad” LDL cholesterol.


The large-scale trial also found that patients taking the drug suffered more non-fatal but serious side effects than those only taking statins.


The medicine was approved for use in Europe in 2008, but U.S. regulators were unwilling to approve it until Merck conducted the costly long-term study to better assess its safety and effectiveness.


Merck said on Thursday that it no longer planned to seek regulatory approval for the drug in the United States and recommended that doctors did not start new patients on Tredaptive in countries where it is already available.


The regulator backed that advice on Friday, but added that patients currently using the drug should speak a doctor at their next appointment but not stop their treatment.


Tredaptive is sold under the brand name Pelzont in Italy and Trevaclyn in both Italy and Portugal. A decision on the future of the drug in Europe is expected in January.


(Reporting by Chris Wickham; Editing by Elaine Hardcastle)


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Research and Markets: Sexual Health Partnering Terms and Agreements






DUBLIN–(BUSINESS WIRE)–


Research and Markets (http://www.researchandmarkets.com/research/v5b7pw/sexual_health) has announced the addition of the “Sexual Health Partnering Terms and Agreements” company profile to their offering.






The Sexual Health Partnering Terms and Agreements report provides comprehensive understanding and unprecedented access to the sexual health partnering deals and agreements entered into by the worlds leading healthcare companies.


The report provides a detailed understanding and analysis of how and why companies enter sexual health partnering deals. The majority of deals are discovery or development stage whereby the licensee obtains a right or an option right to license the licensors sexual health technology. These deals tend to be multicomponent, starting with collaborative R&D, and commercialization of outcomes.


Understanding the flexibility of a prospective partner’s negotiated deals terms provides critical insight into the negotiation process in terms of what you can expect to achieve during the negotiation of terms. Whilst many smaller companies will be seeking details of the payments clauses, the devil is in the detail in terms of how payments are triggered – contract documents provide this insight where press releases do not.


This report contains over 500 links to online copies of actual sexual health deals and contract documents as submitted to the Securities Exchange Commission by companies and their partners. Contract documents provide the answers to numerous questions about a prospective partner’s flexibility on a wide range of important issues, many of which will have a significant impact on each party’s ability to derive value from the deal.


In addition, a comprehensive appendix is provided with each report of all sexual health partnering deals signed and announced since 2007. The appendices are organized by company A-Z, stage of development at signing, deal type (collaborative R&D, co-promotion, licensing etc) and technology type. Each deal title links via Weblink to an online version of the deal record and where available, the contract document, providing easy access to each contract document on demand.


The report also includes numerous tables and figures that illustrate the trends and activities in sexual health partnering and dealmaking since 2007.


In conclusion, this report provides everything a prospective dealmaker needs to know about partnering in the research, development and commercialization of sexual health technologies and products.


Company profiles:


- Abbott


- Bayer


- GlaxoSmithKline


- Menarini


- Merck & Co


- Mylan


- Pfizer


- Roche


- Teva


- Valeant


- Warner Chilcott


- Watson


For more information visit http://www.researchandmarkets.com/research/v5b7pw/sexual_health


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Oncothyreon lung cancer drug fails in late-stage trial






(Reuters) – Biopharmaceutical company Oncothyreon Inc said a late-stage trial of its experimental lung cancer drug did not meet the main study goal of improving overall survival.


The drug, codenamed L-BLP25, is being tested in patients with unresectable, locally advanced stage IIIA or stage IIIB, non-small cell lung cancer (NSCLC).






The trial was conducted by Merck Serono, a division of Germany’s Merck KGaA, under a license agreement with Oncothyreon.


(Reporting by Esha Dey in Bangalore; Editing by Roshni Menon)


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Saudi Arabia bans Brazil beef imports on mad cow doubts






SAO PAULO (Reuters) – Saudi Arabia has suspended imports of Brazilian beef, Brazil‘s agriculture ministry said on Tuesday, and became the largest country to stop purchases after confirmation of a 2010 case of atypical mad cow disease.


The decision, confirmed by a ministry press official in Brasilia, follows Egypt‘s ban of beef on Monday from Parana state, where a cow that died two years ago had developed atypical bovine spongiform encephalopathy (BSE), or mad cow disease. Egypt will continue to import from other states.






Between January and October, Saudi Arabia imported 31,300 metric tons of beef, putting it among the top 10 largest importers from Brazil, the world’s largest beef exporter.


But top buyers Russia, Hong Kong and Egypt – which took more than half of the 896,000 metric tons of beef that Brazil has exported this year through September – continue to import its beef, suggesting the impact could be limited.


Prior to Saudi Arabia, only Japan, China and South Africa had halted imports of all Brazilian beef since Brazil announced on December 7 that a 13-year-old cow that died in 2010 in Parana tested positive for the protein linked to the development of BSE.


The countries are all minor importers of Brazilian beef.


The cow, which was kept for breeding purposes, never developed BSE and died of other causes. But it tested positive for the causal agent for BSE, a protein called a prion, which can arise spontaneously in elderly cattle.


A similar case of atypical BSE occurred in the United States in April. Like the Brazilian cow, that animal never entered the food chain and there was no major effect on U.S. beef exports.


Brazilian companies like JBS SA,, the world’s biggest meats producer, as well as rival Minerva SA and food processor Marfrig Alimentos SA have played down the impact of the case on their operations.


After it confirmed the case of atypical BSE, the World Animal Health Organization issued a statement maintaining Brazil’s status as a low-risk country for mad cow disease.


“This classification has been followed by important countries, blocks and consumers,” Minerva said in a statement on Tuesday, adding that sales to Saudi Arabia accounted for approximately 2.5 percent of gross sales so far this year.


(Reporting by Patricia Monteiro and Roberto Samora; Writing by Caroline Stauffer; Editing by Jeffrey Benkoe)


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Enzon Pharma to explore sale of company






(Reuters) – Biotechnology company Enzon Pharmaceuticals Inc said it would explore a possible sale of the company or its corporate assets.


The company also said that based on clinical data it plans to suspend development of its prostate cancer program, which is being tested in an early-stage trial, to conserve capital.






Enzon had total cash, cash equivalents and marketable securities of $ 288.7 million as of September 30.


The company said it has retained Lazard as financial adviser for the review of the potential sale of one or more corporate assets or the entire company.


Enzon, in which activist investor Carl Icahn has a 13.29 percent stake, has two drugs in mid-stage trials and a number of others in early-stage studies.


Shares of Enzon, which has a market capitalization of about $ 200 million, closed at $ 4.57 on Friday on the Nasdaq. The stock has lost a third of its value so far this year.


(Reporting By Vrinda Manocha in Bangalore; Editing by Roshni Menon)


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Child deaths and bitter cold in Syrian refugee camps






ZAATARI, Jordan (Reuters) – One-year-old Ali Ghazawi, born with a heart defect, faced a battle for survival even before his family fled Syria‘s civil war. It was a struggle he lost two weeks ago in the bitter winter cold of a tented refugee camp in north Jordan.


Ali died two days after undergoing a heart operation in Zaatari camp, which houses at least 32,000 refugees who escaped fierce bombardment in Syria’s rebellious southern province of Deraa, cradle of the uprising against President Bashar al-Assad.






“I covered my son with two blankets, but he was not warming up, and he turned blue before he passed away in my hands,” said his sobbing 22-year-old mother, alone with a three-year-old daughter after she left her husband in Deraa and crossed the border in November.


Ali was the fourth baby to die in three weeks in the windswept camp. United Nations aid workers say none of the deaths were the direct result of conditions in Zaatari, yet they highlight the challenge facing relief agencies scrambling to provide basic shelter for half a million refugees in the region.


“These deaths are a result of cumulative factors, some related to shortage in needs and natural causes. But on top of that, the reality that conditions are harsh cannot be ignored,” said Saba Mobaslat, program director at Save the Children.


Jordan, Lebanon and Turkey each host more than 130,000 registered refugees, and relief workers predict the numbers will only increase as violence escalates around the capital Damascus.


Mirroring Syria’s youthful population, almost 65 percent of Jordan’s camp residents are newborns and young children.


“Every night we are getting children as young as four days old, six days old, one week, two weeks old, and it’s a real struggle to try to make sure that everyone survives,” said Andrew Harper, Jordan head of the United Nations High Commissioner for Refugees (UNHCR).


“Women are giving birth on the border, and people are coming across pregnant. It’s a situation where we just need to redouble efforts, particularly as we move into winter, because you have hundreds of pregnant women who cross the border,” Harper said.


Families often send the most vulnerable to safety, he added, so alongside the very young in Zaatari are many older refugees. “Last night we had a couple who were 97 years old,” he said.


“CHILDREN’S CAMP”


Along the main road in the middle of the camp’s muddy and gravel streets, children of all ages race around the makeshift market place that sprang up after the camp opened in July.


Many families join in, out of enterprise or necessity, selling everything from hot falafel to household goods, old clothing and fresh vegetables.


“It’s a children’s camp. You walk into it and there are children everywhere. It’s in your face. The male adults are staying behind, and a woman comes with 10 children without her bread earner,” Mobaslat added.


In one of several UNICEF-run playgrounds, among seesaws, swings and volunteers giving music lessons, the scars of war are fresh in the minds of most children.


“I long for my home, and I hope Bashar falls to get back to my home. It’s much better than here, where we are humiliated,” said Mohammad Ghazawi, 12, who came to play after a break from selling cheap cigarettes.


Their elders complain that two thin blankets per refugee distributed in recent weeks were not enough to warm them in tents that let in rain water despite zinc reinforcements and waterproof layers that have helped insulate them.


“Kids are dying from cold and lack of blankets. My kids shiver at night, and one has constant diarrhea,” said Mohammad Samara, 46, who fled heavy shelling in the southern Syrian town of Busr al-Sham in October with his wife and four children.


Carsten Hansen, country director for the Norwegian Refugee Council (NRC), which has set up a heated tent that receives families on arrival, says much progress has been made to help distribute aid.


“Everybody is trying to mobilize resources … in order to react to bigger numbers and a huge influx,” Hansen said, adding that 6,000 gas heaters had been airlifted to Jordan to help heat the tent camp.


FROM CRISIS TO DISASTER?


Harper said UNHCR was working to prevent “this humanitarian crisis becoming a major disaster”. But he said that while aid teams were racing to improve conditions at Zaatari, there were 100,000 other registered refugees living outside the camp and probably another 100,000 unregistered, whose living conditions were not improving.


In Lebanon, too, host to 154,000 refugees, many face a bleak winter, and aid workers expect their numbers to more than double by the middle of next year.


In the Bekaa Valley town of Bar Elias, a woman from the northern Syria province of Idlib says her home for the last year has been a wooden shack with only plastic sheeting to protect from the rain. Plastic bags are stuffed into the roof as extra insurance against leaks. “There is no water, no electricity, no school for my kids,” she said in a croaky voice.


“My husband is sick. The situation is very bad.”


Mads Almaas, NRC country director in Lebanon, said many more may flee Syria over the winter to escape worsening conditions there, putting even greater strain on relief efforts.


“The violence will not only continue but also get worse. And even in the increasingly likely event of the fall of Assad, we don’t think the violence will end,” he said.


Almaas said the United Nations would launch a regional response plan on Wednesday anticipating a total of 300,000 registered refugees in Lebanon by mid-2013. “At first we thought it was too high. Now we are concerned it is too low,” he said.


In Turkey, which hosts 136,000 refugees, camps for the most part have facilities such as portable electric heaters, and refugees receive three hot meals a day from the Red Crescent. But temperatures can plunge below freezing in the rugged terrain along the 900 kilometer (560 mile) border with Syria during the winter months, and rain can be torrential and cause flooding.


Overcrowding remains a concern, with extended families cramped in single tents and ever more refugees arriving as fighting across the border drags on.


Across the region, aid workers fear an explosion in violence could leave them seriously overstretched.


“Right now funds are sufficient. What is a challenge is if we get any shocks, something like 5,000-10,000 refugees arriving (in Lebanon) in a matter of hours,” Almaas said.


If fighting swept through the center of Damascus, thousands of Syrians could flee to the Lebanese border in a matter of hours. “For that, we are not prepared as the NRC. I also question the international community’s capacity.”


(Additional reporting by Oliver Holmes in Beirut and Nick Tattersall in Ankara; Editing by Dominic Evans and Will Waterman)


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Venezuela’s Chavez in satisfactory condition: government






CARACAS (Reuters) – Venezuela‘s President Hugo Chavez is recovering “satisfactorily” from his cancer surgery in Cuba although the process remains slow, Information Minister Ernesto Villegas said on Friday.


Reading the latest of regular government updates on the socialist leader’s condition, three days after his operation, Villegas said the 58-year-old president had communicated with relatives and sent greetings to all Venezuelans.






“The recovery has been slow but progressive,” he said.


(Reporting by Eyanir Chinea, Writing by Andrew Cawthorne; Editing by Daniel Wallis and Will Dunham)


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US faces task of running dozens of health exchanges






WASHINGTON (Reuters) – Fourteen U.S. states and the District of Columbia so far have told the federal government they plan to operate healthcare exchanges under President Barack Obama‘s reform law, leaving Washington with the daunting task of creating online marketplaces for at least two-thirds of the country.


On the eve of a federal deadline for states to say whether they will run their own exchanges, a top U.S. healthcare policy official told lawmakers that the exchanges will start enrolling eligible families starting on October 1, 2013.






“I am confident that states and the federal government will be ready in ten months, when consumers in all states can begin to apply,” Gary Cohen, director of the Center for Consumer Information and Insurance Oversight, told a health oversight panel in the U.S. House of Representatives.


Cohen, whose agency is part of the U.S. Department of Health and Human Services (HHS), was among federal officials who testified alongside state health authorities at a hearing of the House Energy and Commerce Subcommittee on Health.


In written testimony, Cohen said 15 states have told the administration they will operate their own exchanges. He later explained under questioning that the count comprises 14 states and the District of Columbia.


Separately, HHS officials confirmed the count of 14 states but could not immediately explain why Cohen’s written testimony contained a higher number.


Some experts say the number of states planning to operate their own exchanges could reach 18 by the time the deadline arrives Friday. Still, the nonpartisan Kaiser Family Foundation, which tracks healthcare issues, says only two states – Utah and Florida – remain undecided.


That would leave at least 30 states in which the administration would be required to run exchanges, a challenge that is raising questions about how successfully U.S. officials can implement a key provision of the healthcare reform law, known to opponents and advocates alike as “Obamacare”.


“I don’t envy them for the job that they have,” said Dennis Smith, a former federal healthcare official who now heads health services in Wisconsin, a state that has decided not to pursue its own exchange.


“At the end of the day, you’re trying to connect a buyer to a seller. And the fundamental things required to do that are not yet in place,” he said.


The Patient Protection and Affordable Care Act, which Obama signed into law more than 2-1/2 years ago, is expected to extend health coverage to more than 30 million uninsured Americans. Those who enroll starting in October would be covered by insurance from January 1, 2014.


POLITICAL THEATER


About half of those newly insured individuals would purchase private coverage from online exchanges at federally subsidized rates. Ultimately, the number of people finding coverage through exchanges is expected to reach 26 million, according to the nonpartisan Congressional Budget Office.


The remainder would be covered by expanding the Medicaid program for the poor to cover all adults earning up to 133 percent of the federal poverty level, or about $ 15,000 for individuals and $ 30,600 for a family of four.


Thursday’s hearing provided a political stage for partisan rhetoric about Obama’s health reforms, which have survived repeated Republican repeal efforts, a nail-biting consideration by the Supreme Court and the Presidential election campaign.


Republicans and state officials from Republican-led states complained about compliance costs and accused HHS of delaying the release of vital details and rules needed to move forward on the exchanges and on the planned Medicaid expansion.


“The uncertain regulatory environment and the overall lack of response from HHS are not encouraging the states or the health plans to move forward,” said Representative Michael Burgess, a Texas Republican.


In response, Congressional Democrats and their state allies stressed the law’s benefits for senior citizens, protections for young adults and the sick, and the prospective economic benefits from an expected influx of billions of dollars in federal money.


“The (Republican) move now is to delay implementation under the guise of lack of information,” said Representative Frank Pallone, a New Jersey Democrat.


“The world in fact is not coming to an end,” he added. “The nation will be better because of the Affordable Care Act.”


States that don’t run their own exchanges would opt for one of two alternatives: a federally facilitated exchange that requires minimal state participation, or a federal partnership exchange in which states help by performing certain duties.


Kaiser Family Foundation expects six states to choose the partnership option and two dozen to opt for federally facilitated exchanges. Cohen said the count so far is four partnerships and seven facilitated exchanges.


States have until February 15 to say whether they intend to seek a federal partnership exchange. Four have done so already, Cohen said.


The administration will have to engineer an information technology system capable of processing operations in a way that meet the needs of healthcare consumers in different states.


Experts say the biggest challenge will likely be providing adequate customer service to handle enrollment, as well as fielding a technology system capable of interfacing seamlessly with the system of each state government.


Cohen told the panel the administration is building a website with interactive capabilities and a call center and has begun testing a data services hub to determine eligibility.


(Reporting by David Morgan; Editing by Ros Krasny, Jilian Mincer, Nick Zieminski and David Gregorio)


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